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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
24.55
Human Site:
Y729
Identified Species:
33.75
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
Y729
D
Q
A
T
R
V
A
Y
Q
K
D
R
R
W
R
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
Y729
D
Q
A
T
R
V
A
Y
Q
K
D
R
R
W
R
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
Y728
D
Q
A
T
R
V
A
Y
Q
K
D
R
R
W
R
Dog
Lupus familis
XP_535848
1288
147094
Y729
D
Q
A
T
R
V
A
Y
Q
K
D
R
R
W
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
Y727
D
Q
A
T
R
V
A
Y
Q
R
D
R
R
W
R
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
L681
L
K
E
K
K
E
R
L
T
E
E
L
K
E
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
K564
Q
K
D
S
Q
K
A
K
Q
C
H
E
E
K
L
Chicken
Gallus gallus
NP_989849
1274
145838
F700
E
D
A
T
R
I
A
F
Q
R
D
K
R
W
R
Frog
Xenopus laevis
P50532
1290
146971
F723
D
Q
A
T
R
V
A
F
Q
K
D
K
R
W
R
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
F728
E
Q
A
T
R
V
A
F
Q
K
D
K
R
W
R
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
F724
M
E
Q
A
R
I
A
F
Q
K
D
R
R
W
R
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
L1042
S
Q
D
S
Q
T
K
L
K
A
E
G
E
R
K
Honey Bee
Apis mellifera
XP_396862
1282
148175
Y666
D
Q
A
T
R
I
A
Y
G
H
K
R
F
R
V
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
H735
T
Q
E
A
Q
R
M
H
R
M
P
A
C
R
G
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
L728
E
Q
A
T
K
I
A
L
Q
G
T
K
R
H
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
Y672
D
Q
A
T
R
I
A
Y
G
G
N
R
E
F
R
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
A799
L
K
Q
A
N
N
V
A
Y
G
K
K
R
F
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
100
100
100
N.A.
93.3
0
N.A.
13.3
60
86.6
80
60
6.6
53.3
6.6
46.6
P-Site Similarity:
100
100
100
100
N.A.
100
40
N.A.
33.3
93.3
100
100
80
40
60
26.6
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
60
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
80
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
65
18
0
0
77
6
0
6
0
6
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
6
0
0
6
0
0
% C
% Asp:
48
6
12
0
0
0
0
0
0
0
53
0
0
0
0
% D
% Glu:
18
6
12
0
0
6
0
0
0
6
12
6
18
6
0
% E
% Phe:
0
0
0
0
0
0
0
24
0
0
0
0
6
12
0
% F
% Gly:
0
0
0
0
0
0
0
0
12
18
0
6
0
0
6
% G
% His:
0
0
0
0
0
0
0
6
0
6
6
0
0
6
0
% H
% Ile:
0
0
0
0
0
30
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
18
0
6
12
6
6
6
6
42
12
30
6
6
6
% K
% Leu:
12
0
0
0
0
0
0
18
0
0
0
6
0
0
6
% L
% Met:
6
0
0
0
0
0
6
0
0
6
0
0
0
0
0
% M
% Asn:
0
0
0
0
6
6
0
0
0
0
6
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
6
0
0
0
0
% P
% Gln:
6
71
12
0
18
0
0
0
65
0
0
0
0
0
6
% Q
% Arg:
0
0
0
0
65
6
6
0
6
12
0
48
65
18
71
% R
% Ser:
6
0
0
12
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
6
0
0
65
0
6
0
0
6
0
6
0
0
0
0
% T
% Val:
0
0
0
0
0
42
6
0
0
0
0
0
0
0
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
53
0
% W
% Tyr:
0
0
0
0
0
0
0
42
6
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _